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Publications| 2007 | | | | 1. | Pinton P, Rimessi A Marchi S, Orsini F, Migliaccio E, Giorgio M, Contursi C, Minucci S, Mantovani F, Wieckowski MR, Del Sal G, Pelicci PG, Rizzuto R . (2007) Protein kinase C and prolyl isomerase 1 regulate mitochondrial effects of the lifespan determinant p66Shc. Science. 315:659-663. PMID 7272725 | | | View Publication | | | | 2. | Rimessi A, Rizzuto R, Pinton P . (2007) Differential recruitment of PKC isoforms in HeLa cells during redox stress. Cell Stress & Chaperones. 12:291-298. | | | | 3. | Romagnoli A, Aguiari P, De Stefani D, Leo S, Marchi S, Rimessi A, Zecchini E, Pinton P, Rizzuto R . (2007) The ER/mitochondria Ca2+ crosstalk. Novartis Found Symp. 287:122-131. PMID 18074635 | | | View Publication | | | | 4. | Zecchini E, Siviero R, Giorgi C, Rizzuto R, Pinton P . (2007) Mitochondrial calcium signalling: message of life and death. Italian Journal of Biochemistry. 56(4):235-42. Review. PMID 19192620 | | | View Publication | | | | 2008 | | | | 1. | Aguiari P, Leo, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R . (2008) High glucose induces adipogenic differentiation of muscle-derived stem cells. Proc Natl Acad Sci U S A Jan 29. 105(4):1226-1331. PMID PMC 2234120 | | | View Publication | | | | 2. | Berniakovich I, Trinei M, Stendardo M, Migliaccio E, Minucci S, Bernardi P, Pelicci PG, Giorgio M. (2008) p66Shc-generated Oxidative Signal Promotes Fat Accumulation. J Biol Chem. 283:34283-93. | | | View Publication | | | | 3. | Berry A, Greco A, Giorgio M, Pelicci PG, de Kloet R, Alleva E, Minghetti L, Cirulli F. (2008) Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice. Exp Gerontol. 43:200-8. PMID 18065182 | | | View Publication | | | | 4. | Campanella M, Szabadkai G, Rizzuto R. (2008) Modulation of intracellular Ca2+ signalling in HeLa cells by the apoptotic cell death enhancer PK11195. Biochem Pharmacol. 76:1628-36. PMID PMC 2844953 | | | View Publication | | | | 5. | Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini-Bréchot P. (2008) Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress. Mol Cell. 32:641-51. PMID PMC 2676567 | | | View Publication | | | | 6. | Giorgi C, Romagnoli A, Pinton P, Rizzuto R . (2008) Ca2+ signaling, mitochondria and cell death. Current Molecular Medicine . 8(2):119-30. PMID 18336292 | | | View Publication | | | | 7. | Leo S, Szabadkai G, Rizzuto R. (2008) The mitochondrial antioxidants MitoE(2) and MitoQ(10) increase mitochondrial Ca(2+) load upon cell stimulation by inhibiting Ca(2+) efflux from the organelle. Ann N Y Acad Sci. 1147:264-74. PMID 19076448 | | | View Publication | | | | 8. | Li C and Li H. (2008) Network-constrained regularization and variable selection for analysis of genomic data. Bioinformatics. 24(21):2566-8; author reply 2569. Epub 2008 Aug 4. PMID 18310618 | | | View Publication | | | | 9. | Marchi S, Rimessi A, Giorgi C, Baldini C, Ferroni L, Rizzuto R, Pinton P. (2008) Akt kinase reducing endoplasmic reticulum Ca2+ release protects cells from
Ca2+-dependent apoptotic stimuli. Biochem Biophys Res Commun. 31(375):501-5. PMID PMC 2576286 | | | View Publication | | | | 10. | Martin-Padura I, de Nigris F, Migliaccio E, Mansueto G, Minardi S, Rienzo M, Lerman LO, Stendardo M, Giorgio M, De Rosa G, Pelicci PG, Napoli C. (2008) p66(Shc) Deletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice. Endothelium. 15:276-87. PMID 19065319 | | | View Publication | | | | 11. | Pinton P, Giorgi C, Siviero R, Zecchini E, Rizzuto R. (2008) Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene. 27:6407-18. PMID PMC 2844952 | | | View Publication | | | | 12. | Pinton P, Rizzuto R. (2008) p66Shc, oxidative stress and aging: importing a lifespan determinant into mitochondria. Cell Cycle . 7:304-8. PMID PMC 2696632 | | | View Publication | | | | 13. | Rimessi A, Giorgi C, Pinton P, Rizzuto R. (2008) The versatility of mitochondrial calcium signals: from stimulation of cell metabolism to induction of cell death. Biochim Biophys Acta. 1777:808-16. PMID PMC 2532847 | | | View Publication | | | | 14. | Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M, Criollo A, Morselli E, Zhu C, Harper F, Nannmark U, Samara C, Pinton P, Vicencio JM, Carnuccio R, Moll UM, Madeo F, Paterlini-Brechot P, Rizzuto R, Szabadkai G, Pierron G, Blomgren K, Tavernarakis N, Codogno P, Cecconi F, Kroemer G. (2008) Regulation of autophagy by cytoplasmic p53. Nat Cell Biol. 10:676-87. PMID PMC 2676564 | | | View Publication | | | | 2009 | | | | 1. | Adinolfi E, Callegari MG, Cirillo M, Pinton P, Giorgi C, Cavagna D, Rizzuto R, Di Virgilio F. (2009) Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem. 284:10120-10128. PMID PMC 2665066 | | | View Publication | | | | 2. | Brennan KM, Michal JJ, Ramsey JJ, Johnson KA . (2009) Body weight loss in beef cows: I. The effect of increased beta-oxidation on mRNA levels of uncoupling proteins 2 and 3 and peroxisome proliferator-activated receptor in the skeletal muscle of beef cows. J. Anim. Sci. 87:2860-2866. PMID 19465504 | | | View Publication | | | | 3. | Carpi A, Menabò R, Kaludercic N, Pelicci P, Di Lisa F, Giorgio M. (2009) The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta. 1787(7):774-80. Epub 2009 Apr 9. PMID 19362067 | | | View Publication | | | | 4. | Di Lisa F, Kaludercic N, Carpi A, Menabo R, Giorgio M. (2009) Mitochondria and vascular pathology. Pharmacol Rep. 61:123-30. PMID 19307700 | | | View Publication | | | | 5. | Di Lisa F, Kaludercic N, Carpi A, Menabo R, Giorgio M. (2009) Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase. Basic Res Cardiol. 104:131-9. PMID 19242637 | | | View Publication | | | | 6. | Giorgi C, De Stefani D, Bononi A, Rizzuto R, Pinton P. (2009) Structural and functional link between the mitochondrial network and the endoplasmic reticulum. Int J Biochem Cell Biol. 41:1817-1827. PMID PMC 2731816 | | | View Publication | | | | 7. | Hagopian K, Ramsey JJ, Weindruch R. (2009) Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver. Biogerontology. Aug. 10(4):471-9. PMID PMC 2700840 | | | View Publication | | | | 8. | Hayashi T, Rizzuto R, Hajnoczky G, Su TP. (2009) MAM: more than just a housekeeper. Trends Cell Biol. 19(2):19(2):81-8. Review. PMID PMC 2750097 | | | View Publication | | | | 9. | Murgia M, Giorgi C, Pinton P, Rizzuto R. (2009) Controlling metabolism and cell death: at the heart of mitochondrial calcium signalling. J Mol Cell Cardiol. 46:781-788. PMID PMC 2851099 | | | View Publication | | | | 10. | Murphy E, Bers D, Rizzuto R. (2009) Mitochondria: from basic biology to cardiovascular disease. J Mol Cell Cardiol. 46(6):765-766. PMID PMC 2700026 | | | View Publication | | | | 11. | Rimessi A, Marchi S, Fotino C, Romagnoli A, Huebner K, Croce CM, Pinton P, Rizzuto R. (2009) Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis. Proc Natl Acad Sci U S A. 106(31):12753-8. Epub 2009 Jul 21. PMID PMC 2722368 | | | View Publication | | | | 12. | Rizzuto R, Marchi S, Bonora M, Aguiari P, Bononi A, De Stefani D, Giorgi C, Leo S, Rimessi A, Siviero R., et al. (2009) Ca(2+) transfer from the ER to mitochondria: when, how and why. Biochim Biophys Acta. 1787:1342-1351. PMID PMC 2730423 | | | View Publication | | | | 13. | Rolo AP, Palmeira CM, Cortopassi GA. (2009) Biosensor plates detect mitochondrial physiological regulators and mutations in vivo. Anal Biochem. 385(1):176-8. PMID PMC 2656379 | | | View Publication | | | | 14. | Silva JM, Wong A, Carelli V, Cortopassi GA. (2009) Inhibition of mitochondrial function induces an integrated stress response in oligodendroglia. Neurobiol Dis. 34(2):357-65. Epub 2009 Feb 20. PMID 19233273 | | | View Publication | | | | 15. | Trinei, Mirella, Ina Berniakovich, Elena Beltrami, Enrica Migliaccio, Ambrogio Fassina, PierGiuseppe Pelicci and Marco Giorgio. (2009) P66Shc signals to age. Aging. 1:503-585. PMID PMC 2806035 | | | View Publication | | | | 16. | Zakharkin SO, Ryan DJ, Mueth N, Kim K. (2009) Performance of Algorithms for Chemometric Calibration. The Joint Statistical Meeting (JSM). August 1-6, 2009. Washington DC. | | | | 2010 | | | | 1. | Berry A, Carnevale D, Giorgio M, Pelicci PG, de Kloet ER, Alleva E, Minghetti L, Cirulli. (2010) Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice. F. Exp Gerontol. 45:343-50. PMID 20085805 | | | View Publication | | | | 2. | Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB. (2010) Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 285(1):142-52. PMID PMC 2844159 | | | View Publication | | | | 3. | Duveau DY, Arce PM, Schoenfeld RA, Raghav N, Cortopassi GA, Hecht SM. (2010) Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria. Bioorg Med Chem 2010 Sep 1. 18(17):6429-41. PMID 20691600 | | | View Publication | | | | 4. | Fadini GP, Albiero M, Menegazzo L, Boscaro E, Pagnin E, Iori E, Cosma C, Lapolla A, Pengo V, Stendardo M, Agostini C, Pelicci PG, Giorgio M, Avogaro A. (2010) The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing. Diabetes. 59:2306-14. PMID PMC 2927954 | | | View Publication | | | | 5. | Ferrari D, Pinton P, Campanella M, Callegari MG, Pizzirani C, Rimessi A, Di Virgilio F, Pozzan T, Rizzuto R. (2010) Functional and structural alterations in the endoplasmic reticulum and mitochondria during apoptosis triggered by C(2)-ceramide and CD95/APO-1/FAS receptor stimulation. Biochem Biophys Res Commun. 391(1):575-581. PMID 19941832 | | | View Publication | | | | 6. | Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP. (2010) PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science. 330(6008):1247-51. PMID 21030605. PMCID: PMC3017677 | | | View Publication | | | | 7. | Hagopian K, Weber KL, Hwee DT, Van Eenennaam AL, López-Lluch G, Villalba JM, Burón I, Navas P, German JB, Watkins SM, Chen Y, Wei A, McDonald RB, Ramsey JJ. (2010) Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. PLoS One Sep 13. 5(9):e12696. PMID PMC 2938348 | | | View Publication | | | | 8. | Kikusato M, Ramsey JJ, Amo T, Toyomizu M. (2010) Application of modular kinetic analysis to mitochondrial oxidative phosphorylation in skeletal muscle of birds exposed to acute heat stress. FEBS Lett. 584:3143-3148. PMID 20515690 | | | View Publication | | | | 9. | Kim K and Zakharkin SO. (2010) Application of intersection-union tests for identifying metabolite biomarkers for diagnosis and prognosis. . The Joint Statistical Meeting (JSM) Proceedings. | | | | 10. | Kim K, Zakharkin SO. (2010) Omics Approaches to Obesity and Complex Disorders: Challenges and New Opportunities. In: Anti-Obesity Drug Discovery and Development.. Bentham Science Publisher. In press | | | | 11. | Kim K, Zakharkin SO, Allison DB. (2010) Expectations, validity, and reality of gene expression profiling. Journal of Clinical Epidemiology. 63(9):950-9. PMID PMC 291017 | | | View Publication | | | | 12. | Mammucari C, Rizzuto R. (2010) Signaling pathways in mitochondrial dysfunction and aging. Mech Aging Dev. 131(7-8):536-43. PMID PMC 2948971 | | | View Publication | | | | 13. | Schoenfeld R, Wong A, Silva J, Li M, Itoh A, Horiuchi M, Itoh T, Pleasure D, Cortopassi G. (2010) Oligodendroglial differentiation induces mitochondrial genes and inhibition of mitochondrial function represses oligodendroglial differentiation. Mitochondrion. 10(2):143-50. PMID 20005986 | | | View Publication | | | | 14. | Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA. (2010) Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice. J Biol Chem. 285(2):1153-65. PMID PMC 2801244 | | | View Publication | | | | 2011 | | | | 1. | Anelli T, Bergamelli L, Margittai E, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R, Sitia R. (2011) Ero1? Regulates Ca(2+) Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM). Antioxid Redox Signal. 2011(Oct 19):Epub ahead of print. PMID 21854214 | | | View Publication | | | | 2. | Bonizzi G, Cicalese A, Insinga A, Pelicci PG. (2011) The emerging role of p53 in stem cells. Trends Mol Med. 2011(Sep 7):Epub ahead of print. PMID 21907001 | | | View Publication | | | | 3. | De Stefani D, Bononi A, Romagnoli A, Messina A, De Pinto V, Pinton P, Rizzuto R. (2011) VDAC1 selectively transfers apoptotic Ca(2+) signals to mitochondria. Cell Death Differ. 2011(Jul 1):Epub ahead of print. PMID 21720385 | | | View Publication | | | | 4. | De Stefani D, Raffaello A, Teardo E, Szabò I, Rizzuto R. (2011) A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature. 476(7360):336-40. PMID 21685888 | | | View Publication | | | | 5. | Giorgi C, Romagnoli A, Agnoletto C, Bergamelli L, Sorrentino G, Brini M, Pozzan T, Meldolesi J, Pinton P, Rizzuto R. (2011) Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure. BMC Cell Biol. 12:27. PMID 21658234. PMCID: PMC3138454 | | | View Publication | | | | 6. | Hagopian K, Chen Y, Simmons Domer K, Soo Hoo R, Bentley T, McDonald RB, Ramsey JJ . (2011) Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver. J Bioenerg Biomembr. 2011 Apr 20:Epub ahead of print. PMID 21505800 | | | View Publication | | | | 7. | Mammucari C, Patron M, Granatiero V, Rizzuto R. (2011) Molecules and roles of mitochondrial calcium signaling. Biofactors. 37(3):219-27. PMID 21674643 | | | View Publication | | | | 8. | Pasi CE, Pelicci PG. (2011) Inhibition of epithelial-to-mesenchimal transition: a novel tumor suppressor function of p53?. Cell Cycle. 10(16):2616-7. PMID 21836395 | | | View Publication | | | | 9. | Pesaresi MG, Amori I, Giorgi C, Ferri A, Fiorenzo P, Gabanella F, Salvatore AM, Giorgio M, Pelicci PG, Pinton P, Carrì MT, Cozzolino M. (2011) Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation. Hum Mol Genet. 20(21):4196-208. PMID 21828072 | | | View Publication | | | | 10. | Raffaello A, Rizzuto R. (2011) Mitochondrial longevity pathways. Biochim Biophys Acta. 1813(1):260-8. PMID 20950653 | | | View Publication | | | | 11. | Schiaffino S, Mammucari C. (2011) Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models. Skelet Muscle. 1(1):4. PMID 21798082. PMCID: PMC3143906 | | | View Publication | | | | 12. | Taylor SL and Kim K. (2011) A Jackknife and Voting Classifier Approach to Feature Selection and Classification. Cancer Informatics. 2011(10):133-147. | | | View Publication | | | | 13. | Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA. (2011) The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell. 10(1):55-65. PMID 21040401 | | | View Publication | | | | 14. | Ulivieri C, Fanigliulo D, Masi G, Savino MT, Gamberucci A, Pelicci PG, Baldari CT. (2011) p66Shc is a negative regulator of Fc?RI-dependent signaling in mast cells. J Immunol. 186(9):5095-106. PMID 21430228 | | | View Publication | | | | 15. | Wei A, Fascetti AJ, Liu KJ, Villaverde C, Green AS, Manzanilla EG, Havel PJ, Ramsey JJ. (2011) Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food. J Anim Physiol Anim Nutr (Berl). 95(3):359-67. PMID 21039925 | | | View Publication | | | | 2012 | | | | 1. | Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Young Jung D, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. (2012) Hepatic Src Homology Phosphatase 2 Regulates Energy Balance in Mice. Endocrinology. [Epub ahead of print] PMID 22619361 | | | View Publication | | | | 2. | Chen Y, Hagopian K, Bibus D, Villalba JM, Lόpez-Lluch G, Navas P, Kim K, McDonald RB, Ramsey JJ. (2012) The Influence of dietary lipid composition on liver mitochondria from mice following 1 month of calorie restriction.. Biosci Rep. Dec 13;33(1):83-95. doi: 10.1042/BSR20120060. PMID 23098316 | | | View Publication | | | | 3. | Chen Y, Hagopian K, McDonald RB, Bibus D, Lόpez-Lluch G, Villalba JM, Navas P, Ramsey JJ. (2012) The Influence of Dietary Lipid Composition on Skeletal Muscle Mitochondria From Mice Following 1 Month of Calorie Restriction . J Gerontol A Biol Sci Med Sci. 2012 Nov;67(11):1121-31. . PMID 22503990 | | | View Publication | | | | 4. | De Stefani D, Bononi A, Romagnoli A, Messina A, De Pinto V, Pinton P, Rizzuto R. (2012) VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria. Cell Death Differ. Feb;19(2):267-73. doi: 10.1038/cdd.2011.92. PMID 21720385 | | | View Publication | | | | 5. | Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. (2012) The p66Shc knocked out mice are short lived under natural condition. Aging Cell. Feb;11(1):162-8. doi: 10.1111/j.1474-9726.2011.00770.x. PMID 22081964 | | | View Publication | | | | 6. | Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ. (2012) Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis. Metabolism. Dec;61(12):1703-13. doi: 10.1016/j.metabol.2012.05.007. PMID 22683097 | | | View Publication | | | | 7. | Konstantinidis K, Lederer WJ, Rizzuto R, Kitsis RN. (2012) Mitofusin 2 joins the sarcoplasmic reticulum and mitochondria at the hip to sustain cardiac energetics. Circ Res. Sep 14;111(7):821-3. doi: 10.1161/CIRCRESAHA.112.277269. PMID 22982869 | | | View Publication | | | | 8. | Maltecca F, De Stefani D, Cassina L, Consolato F, Wasilewski M, Scorrano L, Rizzuto R, Casari G. (2012) Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation. Hum Mol Genet, 21(17):3858-70. PMID 22678058 | | | View Publication | | | | 9. | Marcu R, Rapino S, Trinei M, Valenti G, Marcaccio M, Pelicci PG, Paolucci F, Giorgio M. (2012) Electrochemical study of hydrogen peroxide formation in isolated mitochondria . Bioelectrochemistry. 85:21-8 PMID 22197548 | | | View Publication | | | | 10. | Raffaello A, De Stefani D, Rizzuto R. (2012) The mitochondrial Ca(2+) uniporter. Cell Calcium. Jul;52(1):16-21. doi: 10.1016/j.ceca.2012.04.006. Review. PMID 22672876 | | | View Publication | | | | 11. | Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R, Pinton P. (2012) The selective inhibition of nuclear PKCζ restores the effectiveness of chemotherapeutic agents in chemoresistant cells. Cell Cycle. Mar 1;11(5):1040-8. doi: 10.4161/cc.11.5.19520. PMID 22333579 | | | View Publication | | | | 12. | Rizzuto R, De Stefani D, Raffaello A, Mammucari C. (2012) Mitochondria as sensors and regulators of calcium signalling. Nat Rev Mol Cell Biol. Sep;13(9):566-78. doi: 10.1038/nrm3412. Review. PMID 22850819 | | | View Publication | | | | 13. | Shan Y, Cortopassi G. (2012) HSC20 interacts with frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis. Hum Mol Genet. Apr 1;21(7):1457-69. doi: 10.1093/hmg/ddr582. PMID 22171070 | | | View Publication | | | | 14. | Song L, Shan Y, Lloyd KC, Cortopassi GA. (2012) Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression. Hum Mol Genet. Dec 1;21(23):5147-58. doi: 10.1093/hmg/dds365. PMID 22949510 | | | View Publication | | | | 15. | Stern JH, Kim K, Ramsey JJ. (2012) The influence of acute, late-life calorie restriction on whole body energy metabolism in p66Shc(-/-) mice. Mech Ageing Dev. Jun;133(6):414-20. doi: 10.1016/j.mad.2012.05.001. PMID 22588161 | | | View Publication | | | | 16. | Stern JH, Kim K, Ramsey JJ. (2012) The influence of shc proteins and aging on whole body energy expenditure and substrate utilization in mice. PLoS One. 7(11):e48790. doi: 10.1371/journal.pone.0048790. PMID 23144971 | | | View Publication | | | | 17. | Su KG, Savino C, Marracci G, Chaudhary P, Yu X, Morris B, Galipeau D, Giorgio M, Forte M, Bourdette D. (2012) Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis. Eur J Neurosci. Feb;35(4):562-71. doi: 10.1111/j.1460-9568.2011.07972.x. PMID 22277070 | | | View Publication | | | | 18. | Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, Kakoki M, Reiss K, Meggs LG. (2012) Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. Am J Physiol Renal Physiol. Dec 15;303(12):F1629-40. doi: 10.1152/ajprenal.00246.2012. PMID 23019230 | | | View Publication | | | | 2013 | | | | 1. | Beltrami E, Ruggiero A, Busuttil R, Migliaccio E, Pelicci PG, Vijg J, Giorgio M. (2013) Deletion of p66Shc in mice increases the frequency of size-change mutations in the lacZ transgene. Aging Cell. Apr;12(2):177-83. doi: 10.1111/acel.12036. PMID 23237310 | | | View Publication | | | | 2. | Beltrami E, Valtorta S, Moresco R, Marcu R, Belloli S, Fassina A, Fazio F, Pelicci P, Giorgio M. (2013) The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis. Curr Pharm Des. 19(15):2708-14. PMID 23092318 | | | View Publication | | | | 3. | Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. (2013) Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci USA. Jan 8;110(2):648-53. doi: 10.1073/pnas.1218667110. PMID 23267072 | | | View Publication | | | | 4. | Bonora M, Giorgi C, Bononi A, Marchi S, Patergnani S, Rimessi A, Rizzuto R, Pinton P. (2013) Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes. Nat Protoc. Nov;8(11):2105-18. doi: 10.1038/nprot.2013.127. PMID 24113784 | | | View Publication | | | | 5. | Dyar KA, Ciciliot S, Wright LE, Bienso RS, Tagliazucchi GM, Patel VR, Forcato M, Paz MI, Gudiksen A, Solagna F, Albiero M, Moretti I, Eckel-Mahan KL, Baldi P, Sassone-Corsi P, Rizzuto R, Bicciato S, Pilegaard H, Blaauw B, Schiaffino S. (2013) Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Mol Metab. Oct 23;3(1):29-41. doi: 10.1016/j.molmet.2013.10.005. Erratum in: Mol Metab. 2014 Dec;3(9):857. PMID 24567902 | | | View Publication | | | | 6. | Gambino V, De Michele G, Venezia O, Migliaccio P, Dall'Olio V, Bernard L, Minardi SP, Della Fazia MA, Bartoli D, Servillo G, Alcalay M, Luzi L, Giorgio M, Scrable H, Pelicci PG, Migliaccio E. (2013) Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging. Aging Cell. Jun;12(3):435-45. doi: 10.1111/acel.12060. PMID 23448364 | | | View Publication | | | | 7. | Hagopian K, Soo Hoo R, Lόpez-Domίnguez JA, Ramsey JJ. (2013) Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations. Life Sci. Dec 5;93(24):941-8. doi: 10.1016/j.lfs.2013.10.006. PMID 24140885 | | | View Publication | | | | 8. | Marchi S, Lupini L, Patergnani S, Rimessi A, Missiroli S, Bonora M, Bononi A, Corrά F, Giorgi C, De Marchi E, Poletti F, Gafά R, Lanza G, Negrini M, Rizzuto R, Pinton P. (2013) Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25. Curr Biol. Jan 7;23(1):58-63. doi: 10.1016/j.cub.2012.11.026. PMID 23246404 | | | View Publication | | | | 9. | Migliaccio E, Giorgio M, Pelicci PG. (2013) p53 and aging: role of p66Shc. Aging (Albany NY). Jul;5(7):488-9. PMID 23924762 | | | View Publication | | | | 10. | Patron M, Raffaello A, Granatiero V, Tosatto A, Merli G, De Stefani D, Wright L, Pallafacchina G, Terrin A, Mammucari C, Rizzuto R. (2013) The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles. J Biol Chem. Apr 12;288(15):10750-8. doi: 10.1074/jbc.R112.420752. Review. PMID 23400777 | | | View Publication | | | | 11. | Raffaello A, De Stefani D, Sabbadin D, Teardo E, Merli G, Picard A, Checchetto V, Moro S, Szabί I, Rizzuto R. (2013) The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit. EMBO J. Aug 28;32(17):2362-76. doi: 10.1038/emboj.2013.157. PMID 23900286 | | | View Publication | | | | 12. | Savino C, Pelicci P, Giorgio M. (2013) The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. Oxid Med Cell Longev. :2013:719407. doi: 10.1155/2013/719407. PMID 23766859 | | | View Publication | | | | 13. | Taylor SL, Leiserowitz GS, Kim K. (2013) Accounting for undetected compounds in statistical analyses of mass spectrometry 'omic studies. Stat Appl Genet Mol Biol. Dec;12(6):703-22. doi: 10.1515/sagmb-2013-0021. PMID 24246290 | | | View Publication | | | | 14. | Trinei M, Migliaccio E, Bernardi P, Paolucci F, Pelicci P, Giorgio M. (2013) p66Shc, mitochondria, and the generation of reactive oxygen species. Methods Enzymol. :528:99-110. doi: 10.1016/B978-0-12-405881-1.00006-9. PMID 23849861 | | | View Publication | | | | 2014 | | | | 1. | Chen Y, Hagopian K, Bibus D, Villalba JM, Lόpez-Lluch G, Navas P, Kim K, Ramsey JJ. (2014) The influence of dietary lipid composition on skeletal muscle mitochondria from mice following eight months of calorie restriction. Physiol Res. 63(1):57-71. PMID 24182343 | | | View Publication | | | | 2. | Granatiero V, Patron M, Tosatto A, Merli G, Rizzuto R. (2014) The use of aequorin and its variants for Ca2+ measurements. Cold Spring Harb Protoc. Jan 1;2014(1):9-16. doi: 10.1101/pdb.top066118. PMID 24371311 | | | View Publication | | | | 3. | Granatiero V, Patron M, Tosatto A, Merli G, Rizzuto R. (2014) Using targeted variants of aequorin to measure Ca2+ levels in intracellular organelles. Cold Spring Harb Protoc. Jan 1;2014(1):86-93. doi: 10.1101/pdb.prot072843. PMID 24371314 | | | View Publication | | | | 4. | Hayashi G, Shen Y, Pedersen TL, Newman JW, Pook M, Cortopassi G. (2014) Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. Dec 20;23(25):6838-47. doi: 10.1093/hmg/ddu407. PMID 25104852 | | | View Publication | | | | 5. | Hill JM, De Stefani D, Jones AW, Ruiz A, Rizzuto R, Szabadkai G. (2014) Measuring baseline Ca(2+) levels in subcellular compartments using genetically engineered fluorescent indicators. Methods Enzymol. 543:47-72. doi: 10.1016/B978-0-12-801329-8.00003-9. PMID 24924127 | | | View Publication | | | | 6. | Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R; UK10K Consortium., Duchen MR, Muntoni F, Sheridan E. (2014) Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling.. Nat Genet. Feb;46(2):188-93. doi: 10.1038/ng.2851. PMID 24336167 | | | View Publication | | | | 7. | Patron M, Checchetto V, Raffaello A, Teardo E, Vecellio Reane D, Mantoan M, Granatiero V, Szabό I, De Stefani D, Rizzuto R. (2014) MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity. Mol Cell. Mar 6;53(5):726- 37. doi: 10.1016/j.molcel.2014.01.013. PMID 24560927 | | | View Publication | | | | 8. | Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB. (2014) The influence of Shc proteins on life span in mice. J Gerontol A Biol Sci Med Sci. Oct;69(10):1177-85. doi: 10.1093/gerona/glt198. PMID 24336818 | | | View Publication | | | | 9. | Sahdeo S, Scott BD, McMackin MZ, Jasoliya M, Brown B, Wulff H, Perlman SL, Pook MA, Cortopassi GA. (2014) Dyclonine rescues frataxin deficiency in animal models and buccal cells of patients with Friedreich's ataxia. Hum Mol Genet. Dec 20;23(25):6848-62. doi: 10.1093/hmg/ddu408. PMID 25113747 | | | View Publication | | | | 10. | Sahdeo S, Tomilov A, Komachi K, Iwahashi C, Datta S, Hughes O, Hagerman P, Cortopassi G. (2014) High-throughput screening of FDAapproved drugs using oxygen biosensor plates reveals secondary mitofunctional effects. Mitochondrion. Jul;17:116-25. doi: 10.1016/j.mito.2014.07.002. PMID 25034306 | | | View Publication | | | | 11. | Stern JH, Kim K, Ramsey JJ. (2014) The influence of shc proteins on the whole body energetic response to calorie restriction initiated in 3- month-old mice. ISRN Nutr. Feb 17:2014:562075. doi: 10.1155/2014/562075. PMID 24967271 | | | View Publication | | | | 12. | Tomilov A, Bettaieb A, Kim K, Sahdeo S, Tomilova N, Lam A, Hagopian K, Connell M, Fong J, Rowland D, Griffey S, Ramsey J, Haj F, Cortopassi G. (2014) Shc depletion stimulates brown fat activity in vivo and in vitro. Aging Cell. Dec;13(6):1049-58. doi: 10.1111/acel.12267. PMID 25257068 | | | View Publication | | | | 2015 | | | | 1. | De Stefani D, Patron M, Rizzuto R. (2015) Structure and function of the mitochondrial calcium uniporter complex. Biochim Biophys Acta. Sep;1853(9):2006-11. doi: 10.1016/j.bbamcr.2015.04.008. Review. PMID 25896525 | | | View Publication | | | | 2. | Hagopian K, Tomilov AA, Kim K, Cortopassi GA, Ramsey JJ. (2015) Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS One. Apr 16;10(4):e0124204. doi: 10.1371/journal.pone.0124204. PMID 25880638 | | | View Publication | | | | 3. | Hayashi G, Cortopassi G. (2015) Oxidative stress in inherited mitochondrial diseases. Free Radic Biol Med. Nov;88(Pt A):10-7. doi: 10.1016/j.freeradbiomed.2015.05.039. Review. PMID 26073122 | | | View Publication | | | | 4. | Lόpez-Domίnguez JA, Ramsey JJ, Tran D, Imai DM, Koehne A, Laing ST, Griffey SM, Kim K, Taylor SL, Hagopian K, Villalba JM, Lόpez-Lluch G, Navas P, McDonald RB. (2015) The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice. J Gerontol A Biol Sci Med Sci. Oct;70(10):1181-8. doi: 10.1093/gerona/glu177. PMID 25313149 | | | View Publication | | | | 5. | Mammucari C, Gherardi G, Zamparo I, Raffaello A, Boncompagni S, Chemello F, Cagnin S, Braga A, Zanin S, Pallafacchina G, Zentilin L, Sandri M, De Stefani D, Protasi F, Lanfranchi G, Rizzuto R. (2015) The mitochondrial calcium uniporter controls skeletal muscle trophism in vivo. Cell Rep. Mar 3;10(8):1269-79. doi: 10.1016/j.celrep.2015.01.056. PMID 25732818 | | | View Publication | | | | 6. | Murgia M, Rizzuto R. (2015) Molecular diversity and pleiotropic role of the mitochondrial calcium uniporter. Cell Calcium. Jul;58(1):11-7. doi: 10.1016/j.ceca.2014.11.001. Review. PMID 26048007 | | | View Publication | | | | 7. | Song L, Cortopassi G. (2015) Mitochondrial complex I defects increase ubiquitin in substantia nigra. Brain Res. Jan 12:1594:82-91. doi: 10.1016/j.brainres.2014.11.013. PMID 25446449 | | | View Publication | | | | 2016 | | | | 1. | Datta S, Sahdeo S, Gray JA, Morriseau C, Hammock BD, Cortopassi G. (2016) A high-throughput screen for mitochondrial function reveals known and novel mitochondrial toxicants in a library of environmental agents. Mitochondrion. Nov;31:79-83. doi: 10.1016/j.mito.2016.10.001. PMID 27717841 | | | View Publication | | | | 2. | Datta S, Tomilov A, Cortopassi G. (2016) Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutations. Mitochondrion. Sep;30:177-86. doi: 10.1016/j.mito.2016.08.002. PMID 27497748 | | | View Publication | | | | 3. | Granatiero V, Giorgio V, Calί T, Patron M, Brini M, Bernardi P, Tiranti V, Zeviani M, Pallafacchina G, De Stefani D, Rizzuto R. (2016) Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase. Cell Death Differ. Feb;23(2):231-41. doi: 10.1038/cdd.2015.84. PMID 26206091 | | | View Publication | | | | 4. | Hagopian K, Kim K, López-Dominguez JA, Tomilov AA, Cortopassi GA, Ramsey JJ. (2016) Mice with low levels of Shc proteins display reduced glycolytic and increased gluconeogenic activities in liver. Biochem Biophys Rep. :Sep;7:273-286. doi: 10.1016/j.bbrep.2016.06.021. Epub 2016 Jun 30. PMID 8133633 | | | | 5. | McMackin MZ, Henderson CK, Cortopassi GA. (2016) Neurobehavioral deficits in the KIKO mouse model of Friedreich's ataxia. Behav Brain Res. 2017 Jan 1:316:183-188. doi: 10.1016/j.bbr.2016.08.053. PMID 27575947 | | | View Publication | | | | 6. | Raffaello A, Mammucari C, Gherardi G, Rizzuto R. (2016) Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes. Trends Biochem Sci. Dec;41(12):1035-1049. doi: 10.1016/j.tibs.2016.09.001. Review. PMID 27692849 | | | View Publication | | | | 7. | Shen Y, McMackin MZ, Shan Y, Raetz A, David S, Cortopassi G. (2016) Frataxin Deficiency Promotes Excess Microglial DNA Damage and Inflammation that Is Rescued by PJ34. PLoS One. Mar 8;11(3):e0151026. doi: 10.1371/journal.pone.0151026. PMID 26954031 | | | View Publication | | | | 8. | Taylor SL, Ruhaak LR, Kelly K, Weiss RH, Kim K. (2016) Effects of imputation on correlation: implications for analysis of mass spectrometry data from multiple biological matrices. Brief Bioinform. Feb 19:pii: bbw010. [Epub ahead of print]. PMID 26896791. 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PMID 27138568 | | | View Publication | | | | 2017 | | | | 1. | Datta S, Baudouin C, Brignole-Baudouin F, Denoyer A, Cortopassi GA. (2017) The Eye Drop Preservative Benzalkonium Chloride Potently Induces Mitochondrial Dysfunction and Preferentially Affects LHON Mutant Cells. Invest Ophthalmol Vis Sci. Apr 1;58(4):2406- 2412(doi: 10.1167/iovs.16-20903):pages. PMID 28444329 | | | View Publication | | | | 2. | Roberts MN, Wallace MA, Tomilov AA, Zhou Z, Marcotte GR, Tran D, Perez G, Gutierrez-Casado E, Koike S, Knotts TA, Imai DM, Griffey SM, Kim K, Hagopian K, Haj FG, Baar K, Cortopassi GA, Ramsey JJ, Lopez- Dominguez JA.. (2017) A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. Sep 5;26(3):539-546.e5(doi: 10.1016/j.cmet.2017.08.005.):pages. PMID 28877457 | | | View Publication | | | | 3. | Song L, Yu A, Murray K, Cortopassi G. (2017) Bipolar cell reduction precedes retinal ganglion neuron loss in a complex 1 knockout mouse model. Brain Res. Feb 15(1657:232-244):pages. PMID 28027875 | | | View Publication | | | | 4. | Taylor SL, Ruhaak LR, Weiss RH, Kelly K, Kim K. (2017) Multivariate twopart statistics for analysis of correlated mass spectrometry data from multiple biological specimens. Bioinformatics. Jan 1:pages. PMID 27592710 | | | View Publication | | |
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