OVERVIEW

The p66Shc program is a multi-disciplinary project that consists of researchers from the University of California, Davis, USA, the Istituto Europeo di Oncologia, Milan, Italy, and the Università degli Studi di Padova, Padova, Italy.

This program project is supported by the U.S. National Institutes of Health National Institute on Aging (http://www.nia.nih.gov)

The goals of the program project are to identify the Shc-based mechanism of: 1) decreased adiposity and increased survival on high-fat diet in mutant mice, 2) extended median lifespan on caloric restriction, and 3) improved stem cell function. In addition, the program is working to 4) identify drugs and diets that simulate Shc-deficiency to be used as leads to promote healthy human aging. Thus, the ultimate product of the program will be not only a detailed understanding of the anti-obesity mechanism, anti-diabetic and anti-stress functions of Shcs, but also lead compounds and nutritional interventions that support healthy aging.